In 1889, William Osler became the first Physician-in-Chief of the new Johns Hopkins Hospital in Baltimore, MD. Four years later, he opened the Johns Hopkins School of Medicine where he would transform medical education over the next ten years. Most of our current conventions in medical teaching, including rounding and residencies, date back to Dr. Osler. He was instrumental in placing the patient at the center of the educational experience, moving students out of the classroom and into a hospital room. He was quoted as saying, “Listen to your patient, he is telling you the diagnosis”. As I began my neurology residency, 113 years after its founding, I was a member of the Hopkins training legacy and a beneficiary of Osler’s educational philosophy. I have learned more about transverse myelitis, acute flaccid myelitis, acute disseminated encephalomyelitis and neuromyelitis optica spectrum disorder by listening to my patients than from any book, lecture or experiment. I have learned more about ADEM, AFM, NMOSD, ON and TM from the families of my patients than any medical school class.